院長の英文原著論文（４８論文）

1. Mussell, M.J., Nakazono, Y., Miyamoto, Y., Okabe, S. and Takishima, T. 1990. Distinguishing normal and abnormal tracheal breathing sounds by principal component analysis. Japanese Journal of Physiology 40:713-721.

2. Satoh, M., Hida, W., Chonan, T., Miki, H., Iwase, N., Taguchi, O., Okabe, S., Kikuchi, Y. and Takishima, T. 1991. Role of hypoxic drive in regulation of postapneic ventilation during sleep in patients with obstructive sleep apnea. Am. Rev. Respir. Dis. 143:481-485.

3. Chonan, T., Okabe, S., Hida, W., Izumiyama, T., Kikuchi, Y. and Takishima, T. 1991. Inhomogeneous response of expiratory muscle activity to cold block of the ventral medullary surface. J. Appl. Physiol. 71:1723-1728.

4. Chonan, T., Hida, W., Okabe, S., Izumiyama, T., Sakurai, M. and Takishima, T. 1991. Effects of focal cooling of the ventral medullary surface on breathing pattern and blood pressure in dogs. Respiration Physiology 83:77-86.

5. Okabe, S., Chonan, T., Hida, W., Satoh, M., Taguchi, O., Kikuchi, Y., Miki, H., Iwase, N. and Takishima, T. 1991. Genioglossus and inspiratory pump muscle activity during hypoxia, hypercapnia and sleep in patients with obstructive sleep apnea. Advances in the biosciences 79:215-217.

6. Chonan, T., Okabe, S., Hida, W., Izumiyama, T., Sato, M., Sakurai, M., Kikuchi, Y. , Iwase, N., Taguchi, O, Miki, H. and Takishima, T. 1991. Effects of localized cooling of the ventral medullary surface (VMS) on expiratory muscle activity. Advances in the biosciences 79:73- 75.

7. Sato, M., Chonan, T., Hida, W., Okabe, S., Miki, H. , Taguchi, O. ,Kikuchi, Y. , Iwase, N., Miura, C. and Takishima, T. 1991. Load compensation to postural change in patients with obstructive sleep apnea. Advances in the biosciences 79:211-213.

8. Taguchi, O., Kikuchi, Y., Hida, W., Iwase, N., Sato, M., Okabe, S., Chonan, T. and Takishima, T. 1991. PGE2 inhalation increased dyspnea during exercise in normal subjects. Advances in the biosciences 79:355-357.

9. Taguchi, O., Kikuchi, Y., Hida, W., Iwase, N., Okabe, S., Chonan, T. and Takishima, T. 1992. Prostaglandin E2 inhalation increases the sensation of dyspnea during exercise. Am. Rev. Respir. Dis. 145:1346-1349.

10. Iwase, N., Kikuchi, Y., Hida, W., Miki, H., Taguchi, O., Satoh, M., Okabe, S. and Takishima, T. 1992. Effects of repetitive airway obstruction on O2 saturation and systemic and pulmonary arterial pressure in anesthetized dogs. Am. Rev. Respir. Dis. 146:1402-1410.

11. Chonan, T., Hida, W., Okabe, S., Chung, Y.,Kikuchi, Y. and Takishima, T. 1992. Does sustained hypoxia have biphasic effects on the sensation of dyspnea? In: Control of breathing and its modeling perspective, Y Honda eds. Plenum Press, New York, pp.183-186.

12. Hida, W., Okabe, S., Ebihara, S., Chonan, T., Kikuchi, Y.and Takishima, T. 1992. Serial submental stimulation during sleep in patients with obstructive sleep apnea. In: Control of breathing and its modeling perspective, Y. Honda eds. Plenum Press, New York, pp.337-340.

13. Kikuchi, Y., Sakurai, M., Hida, W., Okabe, S., Chung, Y., shindoh, C., Chonan, T., Kurosawa, H. and Takishima, T. 1992. Effects of changes in breathing pattern on the sensation of dyspnea during inspiratory loaded breathing. In: Control of breathing and its modeling perspective, Y. Honda eds. Plenum Press, New York, pp.405-408.

14. Satoh, M., Hida, W., Chonan, T., Okabe, S., Miki, H., Taguchi, O., Kikuchi, Y. and Takishima, T. 1993. Effects of posture on carbon dioxide responsiveness in patients with obstructive sleep apnoea. Thorax 48:537-541.

15. Okabe, S., Chonan, T., Hida, W., Satoh, M., Kikuchi, Y. and Takishima, T. 1993. Role of chemical drive in recruiting upper airway and inspiratory intercostal muscles in patients with obstructive sleep apnea. Am. Rev. Respir. Dis. 147:190-195.

16. Hida, W., Shindoh, C., Miki, H., Kikuchi, Y., Okabe, S., Taguchi, O., Takishima, T. and Shirato, K. 1993. Prevalence of sleep apnea among Japanese industrial workers determined by a portable sleep monitoring system. Respiration 60:332-337.

17. Okabe, S., Hida, W., Kikuchi, Y., Kurosawa, H., Midorikawa, J., Chonan, T., Takishima, T. and Shirato, K. 1993. Upper airway muscle activity during sustained hypoxia in awake humans. J. Appl. Physiol. 75:1552-1558.

18. Okabe, S., Hida, W., Kikuchi, Y., Taguchi, O., Takishima, T. and Shirato, K. 1994. Upper airway muscle activity during REM and non-REM sleep of patients with obstructive apnea. Chest 106:767-773.

19. Hida, W., Okabe, S., Miki, H., Kikuchi, Y., Taguchi, O., Takishima, T. and Shirato, K. 1994. Effects of submental stimulation for several consecutive nights in patients with obstructive sleep apnoea. Thorax 49:446-452.

20. Kikuchi, Y., Okabe, S., Tamura, G., Hida, W., Homma, M., Shirato, K. and Takishima, T. 1994. Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N. Engl. J. Med. 330:1329-1334.

21. Midorikawa, J., Kikuchi, Y., Taguchi, O., Hida, W., Okabe, S., Takishima, T. and Shirato, K. 1994, Effects of prostaglandin E2 inhalation on hypercapnic response in normal subjects. Am. J. Respir. Crit. Care Med. 150:1592-1597.

22. Mizusawa,A., Ogawa, H., Kikuchi, Y., Hida, W., Kurosawa, H., Okabe, S., Takishima, T. and Shirato, K. 1994. In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J. Physiology 478:55-65.

23. Okabe, S., Gustaw, W. and Kubin L. 1994. Role of GABAB receptors in the control of hypoglossal motoneurons in vivo. NeuroReport 5:2573-2576.

24. Hida, W., Okabe, S., Miki, H., Kikuchi, Y., Kurosawa, H., Takishima, T. and Shirato, K. 1995. Submental stimulation an supraglottic resistance during mouth breathing. Respiration Physiology 101:79-85.

25. Hida, W., Kurosawa, H., Okabe, S., Kikuchi, Y., Midorikawa, J., Chung, Y., Takishima, T. and Shirato, K. 1995. Hypoglossal nerve stimulation affects the pressure-volume behavior of the upper airway. Am. J. Respir. Crit. Care Med. 151:455-460.

26. Okabe, S., Hida, W., Kikuchi, Y., Taguchi, O., Ogawa, H., Mizusawa, A., Miki, H. and Shirato, K. 1995 Role of hypoxia on increased blood pressure in patients with obstructive sleep apnoea. Thorax 50:28-34.

27. Okabe, S., Hida, W., Chonan, T., Izumiyama, T., Kikuchi, Y., Takishima, T. and Shirato, K. 1995 Effect of intramedullary procaine injection on tracheal tone and phrenic neurogram. Respiration Physiology 99:89-96.

28. Hida, W., Kikuchi, Y., Okabe, S., Miki, H., Kurosawa, H. and Shirato, K. 1996. CO2 response for the brain stem artery blood flow velocity in man. Respiration Physiology 104:71 -75.

29. Okabe, S. and Kubin, L. 1996 Role of 5HT1 receptors in the control of hypoglossal motoneurons in vivo. Sleep 19: s150-s153.

30. Midorikawa, J., Hida, W., Taguchi, O., Okabe, S., Kurosawa, H., Mizusawa, A., Ogawa, H., Ebihara, S., Kikuchi, Y. and Shirato, K. 1997. Lack of ventilatory threshold in patients with chronic obstructive pulmonary disease. Respiration 64: 76-80.

31. Fenik, V., Kubin, L., Okabe, S., Pack, A. I. and Davies, R. O. 1997 Differential sensitivity of laryngeal and pharyngeal motoneurons to iontophoretic application of serotonin. Neuroscience 81: 813-819.

32. Okabe, S., Mackiewicz, M. and Kubin, L. 1997. Serotonin receptor mRNA expression in the hypoglossal motor nucleus. Respiration Physiology 110: 151-160.

33. Okabe, S., Sanford, L. D., Veasey, S. C. and Kubin, L. 1997. Pontine injections of nitric oxide synthase inhibitor, L-NAME consolidate episodes of REM sleep in the rat. Sleep research online 1: 41-48.

34. Taguchi O., Hida, W., Okabe, S., Ebihara, S., Ogawa, H., Kikuchi, Y., Shirato, K. 1997. Improvement of exercise performance with short-term nasal continuouos positive airway pressure in patients with obstructive sleep apnea. Tohoku J. Exp. Med. 183: 45-53.

35. Chonan, T., Okabe, S., Hida, W., Satoh, M., Kikuchi, Y., Takishima, T., and Shirato, K. 1998. Influence of sustained hypoxia on the sensation of dyspnea. Japanese Journal of Physiology 48: 291-295.

36. Ye Tun, Okabe, S., Hida, W., Kurosawa, H., Tabata, M., Kikuchi, Y. and Shirato, K. 1999. Nocturnal blood pressure during apnoeic and ventilatory periods in patients with obstructive sleep apnoea. Eur. Respir. J. 14: 1271-1277.

37. Wu, D., Hida, W., Kikuchi, Y., Okabe, S., Kurosawa, H., Ogawa, H. and Shirato, K. 1999. Volume-pressure properties of the upper airway in normal subjects and patients with obstructive sleep apnoea. Respirology 4: 69-75.

38. Ye Tun, Hida, W., Okabe, S., Kikuchi, Y., Kurosawa, H., Tabata, M. and Shirato, K. 2000. Effects of nasal continuous positive airway pressure on awake ventilatory responses to hypoxia and hypercapnia in patients with obstructive sleep apnea. Tohoku J. Exp. Med. 190: 157-168.

39. Onodera, H., Okabe, S., Kikuchi, Y., Tsuda, T. and Itoyama, Y. 2000. Impaired chemosensitivity and perception of dyspnoea in parkinson's disease. Lancet 356:739-740.

40. Ye Tun, Hida, W., Okabe, S., Kikuchi, Y., Kurosawa, H., Tabata, M. and Shirato, K. 2000. Inspiratory effort sensation to added resistive loading in patients with obstructive sleep apnea. Chest 118: 1332-1338.

41. Onodera, H., Okabe, S., Kikuchi, Y., Tsuda, T. and Itoyama, Y. 2000. Parkinson's disease and impaired chemosensitivity to hypoxia. Lancet 356: 2099.

42. Tabata, M., Kurosawa, H., Kikuchi, Y., Hida, W., Ogawa, H., Okabe, S., Tun, Y., Hattori, T., Shirato, K. 2001. Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats. Am. J. Physiol. 281: R1411-R1419.

43. Hida, W., Ye Tun, Kikuchi, Y., Okabe, S. and Shirato, K. 2002. Pulmonary hypertension in patients with chronic obstructive pulmonary disease: recent advances in pathophysiology and management. Respirology 7: 3-13.

44. Tsuda, T., Onodera, H., Okabe, S., Kikuchi, Y. and Itoyama, Y. 2002. Impaired chemosensitivity to hypoxia is a marker of multiple system atrophy. Ann. Neurol. 52:367- 371.

45. Ye Tun, Hida, W., Okabe, S. Ogawa, H., Kikuchi, Y., Oikawa, M., Kitamuro, T. and Shirato, K. 2003. Can nasal continuous positive airway pressure decrease clinic blood pressure in patients with obstructive sleep apnea? Tohoku J. Exp. Med. 201: 181-190.

46. Suzuki, M., Ogawa, H., Okabe, S., Yagi, T., Horiuchi, A., Okubo, M., Ikeda, K., Hida, W., Kobayashi, T. 2004. The effect of upper airway structural changes on central chemosensitivity in obstructive sleep apnea-hypopnea. Sleep and brething 8:73-83.

47. Suzuki, M., Ogawa, H., Okabe, S., Horiuchi, A., Okubo, M., Ikeda, K., Hida, W., Kobayashi, T. 2005. Digital recording and analysis of esophageal pressure for patients with obstructive sleep apnea-hypopnea syndrome. Sleep Breath 9:64-72.

48. Takayanagi, M., Okabe, S., Yamamoto, K., Komatsu, J., Suzuki, R., Kitamura, T., Ohura, T. 2017. kline-Levin syndrome elicited by encephalopathy with rebersible splenial lesion. Pediatrics International 59:929-931.

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